An internal standard for the quantification of taurine
Taurine-d4 is intended for use as an internal standard for the quantification of taurine by GC- or LC-MS. Taurine is a sulfur-containing amino acid produced endogenously and also ingested in the diet.1 It is ubiquitously present in most cells and has diverse biological activities, including antioxidative, anticancer, cardioprotective, and neuroprotective properties.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals when used at concentrations ranging from 125 to 1,000 µg/ml and decreases the viability of MCF-7 and MDA-MB-231 human breast cancer cells.2 It prevents left ventricular dysfunction in the mdx mouse model of late-stage Duchenne muscular dystrophy when administered at a dose of 1 g/kg per day for six months.3 Taurine (100 µM) prevents neurotoxicity induced by amyloid-β (Aβ) or the glutamate receptor agonists glutamate, NMDA , or kainic acid in chick embryonic retinal neurons, an effect that can be blocked by the GABAA receptor antagonist picrotoxin .4
1.Schaffer, S., and Kim, H.W.Effects and mechanisms of taurine as a therapeutic agentBiomol. Ther. (Seoul)26(3)225-241(2018) 2.Choi, E.-J., Tang, Y., Lee, C.B., et al.Investigation of antioxidant and anticancer potential of taurine by means of multiple chemical and biological assaysTaurine 9(2018) 3.Mele, A., Manturano, P., De Bellis, M., et al.A long-term treatment with taurine prevents cardiac dysfunction in mdx miceTransl. Res.20482-99(2019) 4.Louzada, P.R., Lima, A.C.P., Mendon?a-Silva, D.L., et al.Taurine prevents the neurotoxicity of ?-amyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer’s disease and other neurological disordersFASEB J.18(3)511-518(2004)
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