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- Checkpoint Kinase (Chk)
- Wee1 Inhibitor
Wee1 Inhibitor
An inhibitor of Wee1
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥2087.001670.00- +
- 货号: ajcx25816
- CAS: 622855-37-2
- 别名:
- 分子式: C20H11ClN2O3
- 分子量: 362.8
- 纯度: ＞98%
- 溶解度: DMSO: 10 mg/ml,Ethanol: 10 mg/ml
- 储存: -20°C
- 库存: 现货
Background
Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM).1 It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 µM for the E. coli enzyme).2
1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006) 2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010)
