A phthalide with antiplatelet and neuroprotective activities
L-3-n-Butylphthalide is a phthalide that has been found in A. graveolens and has antiplatelet and neuroprotective activities.1 It inhibits ADP-, collagen-, and arachidonic acid-induced platelet aggregation ex vivo when administered at doses ranging from 3 to 100 mg/kg and inhibits thrombus formation in a collagen and epinephrine-induced rat model of experimental thrombosis. L-3-n-Butylphthalide (10 and 30 mg/kg per day) reduces amyloid-β-induced decreases in glutathione peroxidase (GPX) activity and decreases malondialdehyde (MDA) levels in the cortex and hippocampus and improves spatial learning and memory in the Morris water maze in a rat model of Alzheimer’s disease induced by intracerebroventricular infusion of amyloid-β (1-40) .2
1.Peng, Y., Zeng, X., Feng, Y., et al.Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in ratsJ. Cardiovasc. Pharmacol.43(6)876-881(2004) 2.Peng, Y., Xing, C., Xu, S., et al.L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in ratsEur. J. Pharmacol.621(1-3)38-45(2009)
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