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- Acyltransferase
- Oleoyl-Coenzyme A (sodium salt)
Oleoyl-Coenzyme A (sodium salt)
酰基辅酶A硫酯
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包装价格促销价数量
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1mg￥475.00380.00- +
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5mg￥2162.001730.00- +
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10mg￥3612.002890.00- +
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25mg￥7125.005700.00- +
- 货号: ajcx25864
- CAS: N/A
- 别名: Oleoyl (cis-9-C18:1)-CoA, Oleoyl-CoA
- 分子式: C39H68N7O17P3S ? Na
- 分子量: 1055
- 纯度: ＞98%
- 溶解度: Water: 10mg/mL
- 储存: Store at -20°C
- 库存: 现货
Background
Oleoyl-coenzyme A (oleoyl-CoA) is a thioester of oleic acid and CoA . It is a substrate for several acyl-CoA-dependent enzymes, including acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), ACAT-2, acyl-CoA dehydrogenase-9 (ACAD-9), membrane-bound O-acyltransferase 1 (MBOAT1), and MBOAT2.1,2,3 Oleoyl-CoA binds the fatty acid metabolism regulator protein (FadR) promoter in E. coli (Ki = 0.005 µM).4 Oleoyl-CoA (1 µM) activates sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 in Xenopus oocytes.5
1.Seo, T., Oelkers, P.M., Giattina, M.R., et al.Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cellsBiochemistry40(15)4756-4762(2001) 2.Ensenauer, R., He, M., Willard, J.-M., et al.Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial β-oxidation of unsaturated fatty acidsJ. Biol. Chem.280(37)32309-32316(2005) 3.Gijón, M.A., Riekhof, W.R., Zarini, S., et al.Lysophospholipid acyltransferases and arachidonate recycling in human neutrophilsJ. Biol. Chem.283(44)30235-30245(2008) 4.DiRusso, C.C., Heimert, T.L., and Metzger, A.K.Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme AJ. Biol. Chem.267(12)8685-8691(1992) 5.Gribble, F.M., Proks, P., Corkey, B.E., et al.Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoAJ. Biol. Chem.273(41)26383-26387(1998)
