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- nAChR/nAChRs (nicotinic acetylcholine receptors)
- (±)-Nornicotine-d4
(±)-Nornicotine-d4
An internal standard for the quantification of (±)-nornicotine
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥525.00420.00- +
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5mg￥2350.001880.00- +
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10mg￥3987.003190.00- +
- 货号: ajcx25914
- CAS: 66148-18-3
- 别名: 氘代降烟碱
- 分子式: C9H8D4N2
- 分子量: 152.2
- 纯度: ＞98%
- 溶解度: Methanol: soluble
- 储存: -20°C
- 库存: 现货
Background
(±)-Nornicotine-d4 is intended for use as an internal standard for the quantification of (±)-nornicotine by GC- or LC-MS. (±)-Nornicotine is an active metabolite of nicotine and a nicotinic acetylcholine receptor (nAChR) agonist.1 It induces currents in Xenopus oocytes expressing human α7 nAChRs or α6 subunit-containing nAChRs (EC50s = 17 and 3.7 µM, respectively). (±)-Nornicotine promotes cell migration and destabilizes cell-cell junctions in EA.hy926 endothelial cells.2 It is self-administered in rats.3,4
1.Papke, R.L., Dwoskin, L.P., and Crooks, P.A.The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: Relevance to nicotine dependence and drug discoveryJ. Neurochem.101(1)160-167(2007) 2.Gagat, M., Grzanka, D., Izdebska, M., et al.Nornicotine impairs endothelial cell-cell adherens junction complexes in EA.hy926 cell line via structural reorganization of F-actinFolia Histochem. Cytobiol.51(3)179-192(2013) 3.Bardo, M.T., Green, T.A., Crooks, P.A., et al.Nornicotine is self-administered intravenously by ratsPsychopharmacology (Berl)146(3)290-296(1999) 4.Hoffman, A.C., and Evans, S.E.Abuse potential of non-nicotine tobacco smoke components: Acetaldehyde, nornicotine, cotinine, and anabasineNicotine Tob. Res.15(3)622-632(2013)
