IRL 1620 (trifluoroacetate salt)

A peptide ETB receptor agonist

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库存: 现货

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500ug

￥1637.00

1310.00

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1mg

￥2625.00

2100.00

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5mg

￥9750.00

7800.00

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货号: ajcx25936
CAS: N/A
别名: PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21)
分子式: C86H117N17O27 ? XCF3COOH
分子量: 1820.9
纯度: >98%
溶解度: Water: soluble
储存: -20°C
库存: 现货

Background

IRL 1620 is a peptide endothelin type B (ET_B) receptor agonist.¹ It selectively binds to ET_B receptors (K_i = 16 pM) over ET_A receptors (IC₅₀ = 1.9 µM) and induces contraction of isolated guinea pig trachea when used at concentrations ranging from 0.01 to 1 µM. IRL 1620 (1 nmol/kg) reduces mean arterial pressure (MAP) in normotensive rats and spontaneously hypertensive rats (SHRs) and diminishes the transient depressor response in SHRs.² It reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia.³ IRL 1620 also improves spatial memory deficits induced by amyloid-β (Aβ) in a rat model of Alzheimer’s disease.

1.Takai, M., Umemura, I., Yamasaki, K., et al.A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptorBiochem. Biophys. Res. Commun.184(2)953-959(1992) 2.James, A.F., Urade, Y., Webb, R.L., et al.IRL 1620, succinyl-[Glu9,Ala11,15]-endothelin-1(8-21), a highly specific agonist of the ETB receptorCardiovasc. Drug Rev.11(3)253-270(1993) 3.Gulati, A., Hornick, M.G., Briyal, S., et al.A novel neuroregenerative approach using ETB receptor agonist, IRL-1620, to treat CNS disordersPhysiol. Res.67(Suppl 1)S95-S113(2018)