Kynurenic acid-d5

Kynurenic acid-d5?是 Kynurenic acid 的氘代物。

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Background

Kynurenic acid-d5 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].

参考文献:
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8.
[3]. Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32.
[4]. Ma?aczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13.

Kynurenic acid-d₅?是 Kynurenic acid 的氘代物。Kynurenic acid 是一种内源性色氨酸代谢物，是针对靶点?NMDA, glutamate, α7 nicotinic acetylcholine receptor?的广谱性拮抗剂，Kynurenic acid 也是?GPR35/CXCR8?的激动剂。