(±)-Ibuprofen-d3 (sodium salt)

An internal standard for the quantification of (±)-ibuprofen

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库存: 现货

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5mg

￥1275.00

1020.00

- +
10mg

￥2237.00

1790.00

- +
25mg

￥5750.00

4600.00

- +
50mg

￥10212.00

8170.00

- +

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货号: ajcx25980
CAS: 1219805-09-0
别名: 布洛芬钠-D3,(±)-Ibuprofen-d3 sodium
分子式: C13H14D3O2 ? Na
分子量: 231.3
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 2 mg/ml
储存: -20°C
库存: 现货

Background

(±)-Ibuprofen-d₃ is intended for use as an internal standard for the quantification of (±)-ibuprofen by GC- or LC-MS. (±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC₅₀s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively).¹ In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED₅₀ = 6.1 mg/kg).² It also inhibits acetic acid-induced writhing in mice (ED₅₀ = 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain.

1.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995) 2.Seguin, L., Le Marouille-Girardon, S., and Millan, M.J.Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: A comparison to other classes of antinociceptive agentPain61(2)325-343(1995)