Thymidine-d4

An internal standard for the quantification of thymidine

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库存: 现货

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1mg

￥1700.00

1360.00

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5mg

￥7200.00

5760.00

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货号: ajcx26004
CAS: 347841-67-2
别名: 胸苷-ALPHA,ALPHA,ALPHA,6-D4,DThyd-d4; NSC 21548-d4
分子式: C10H10D4N2O5
分子量: 246.3
纯度: >98%
溶解度: DMF: 16 mg/mL,DMSO: 10mg/mL,PBS (pH 7.2): 5mg/mL
储存: -20°C
库存: 现货

Background

Thymidine-d₄ is intended for use as an internal standard for the quantification of thymidine by GC- or LC-MS. Thymidine is a pyrimidine nucleoside composed of a deoxyribose sugar and thymine base.¹ It is phosphorylated by thymidine kinase 2 (TK2) in mitochondria to form deoxythymidine monophosphate .² Oral administration of thymidine in combination with deoxycytidine increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency.

1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al.Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiencyAnn. Neurol.81(5)641-652(2017)