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- 5α-Androstan-3β-ol
5α-Androstan-3β-ol
A steroidal androgen
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包装价格促销价数量
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5mg￥562.00450.00- +
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10mg￥1062.00850.00- +
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50mg￥2787.002230.00- +
- 货号: ajcx26028
- CAS: 1224-92-6
- 别名: 5Α-雄甾烷-3Β-醇
- 分子式: C19H32O
- 分子量: 276.5
- 纯度: ＞98%
- 溶解度: Chloroform: soluble
- 储存: -20°C
- 库存: 现货
Background
5α-Androstan-3β-ol is a steroidal androgen.1 It binds to the androgen receptor in a cell-free assay (IC50 = 1.7 µM) and activates the pregnane X receptor (PXR) in HepG2 cells in a reporter assay (EC50 = 0.8 µM).1,2 5α-Androstan-3β-ol also inhibits the androst-4-ene-3,17-dione hydroxylase activities of 16α- and 6β-hydroxylase but not 16β- or 7α-hydroxylase (IC50s = 70, 110, >150, and >150 µM, respectively).3 It decreases testis weight and sperm production in mice when administered at a dose of 30 mg/kg.4
1.Fang, H., Tong, W., Branham, W.S., et al.Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptorChem. Res. Toxicol.16(10)1338-1358(2003) 2.Ekins, S., Chang, C., Mari, S., et al.Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sitesMol. Pharmacol.72(3)592-603(2007) 3.Murray, M., and Mehta, I.Structure-activity relationships in the in vitro modulation of rat hepatic microsomal androst-4-ene-3,17-dione hydroxylase activities by derivatives of 5α- and 5β-androstaneJ. Steroid Biochem.35(3-4)465-471(1990) 4.Martinot, E., Baptissart, M., Véga, A., et al.Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalphaSci. Rep.742182(2017)
