Cu-GTSM

A copper-containing compound with diverse biological activities

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库存: 现货

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数量
1mg

￥537.00

430.00

- +
5mg

￥1612.00

1290.00

- +
10mg

￥2950.00

2360.00

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25mg

￥6650.00

5320.00

- +

已选 0 种 0 瓶

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货号: ajcx26058
CAS: 68341-14-0
别名: CuII(gtsm), copper-GTSM
分子式: C6H10CuN6S2
分子量: 293.9
纯度: >98%
溶解度: DMF: 20 mg/mL,DMSO: 10 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.16 mg/mL
储存: -20°C
库存: 现货

Background

Cu-GTSM is a copper-containing compound and an analog of Cu-ATSM that has diverse biological activities.^1,2,3,4 It is active against methicillin-sensitive and -resistant S. aureus clinical isolates (IC₅₀s = 0.3-0.6 µM for all).¹ Cu-GTSM inhibits the growth of SK-N-MC neuroepithelioma cells and MRC-5 fibroblasts (IC₅₀s = 0.009 and 0.27 µM, respectively).² It induces the production of reactive oxygen species (ROS) in SK-N-MC cells when used at a concentration of 5 µM. Cu-GTSM (2.5 mg/kg) reduces tumor burden in the transgenic adenocarcinoma of mouse prostate (TRAMP) model but induces weight loss and renal toxicity in the same model.³ Cu-GTSM-containing positron-emitting copper isotopes have been used in PET imaging applications for copper trafficking in the TASTPM transgenic mouse model of Alzheimer’s disease.⁴

1.Haeili, M., Moore, C., Davis, C.J.C., et al.Copper complexation screen reveals compounds with potent antibiotic properties against methicillin-resistant Staphylococcus aureusAntimicrob Agents Chemother.58(7)3727-3736(2014) 2.Stefani, C., Al-Eisawi, Z., Jansson, P.J., et al.Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilizationJ. Inorg. Biochem.15220-37(2015) 3.Cater, M.A., Pearson, H.B., Wolyniec, K., et al.Increasing intracellular bioavailable copper selectively targets prostate cancer cellsACS Chem. Biol.8(7)1621-1631(2013) 4.Torres, J.B., Andreozzi, E.M., Dunn, J.T., et al.PET imaging of copper trafficking in a mouse model of alzheimer diseaseJ. Nucl. Med.57(1)109-114(2016)