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  • Akuammine
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Akuammine

An indole alkaloid with analgesic activity

原价
¥1950-13512
价格
1560-10810
Akuammine的二维码

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  • 库存: 现货
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  • 货号: ajcx26214
  • CAS: 3512-87-6
  • 别名: (-)-Akuammine, Vincamajoridine
  • 分子式: C22H26N2O4
  • 分子量: 382.5
  • 纯度: >98%
  • 溶解度: DMF: 2 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
  • 储存: -20°C
  • 库存: 现货

Background


Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity.1 It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis = 0.3, 1.68, and 10.4 µM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s = 2.6 and 0.073 µM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.


1.Creed, S.M., Gutridge, A.M., Argade, M.D., et al.Isolation and pharmacological characterization of six opioidergic Picralima nitida alkaloidsJ. Nat. Prod.84(1)71-80(2021)

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