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  • SABRAC
SABRAC的可视化放大

SABRAC

An inhibitor of acid ceramidase

原价
￥1062-5750
价格
￥ 850-4600
SABRAC的二维码

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  • 库存: 现货
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  • 货号: ajcx26272
  • CAS: 886212-98-2
  • 别名:
  • 分子式: C20H40BrNO3
  • 分子量: 422.4
  • 纯度: >98%
  • 溶解度: Chloroform: soluble
  • 储存: -20°C
  • 库存: 现货

Background


SABRAC is an inhibitor of acid ceramidase (IC50 = 52 nM).1 It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 µM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = <1 µM), as well as induces accumulation of ceramides in the same cells. It completely inhibits anchorage-independent colony formation but does not induce cytotoxicity in PC3 MC cells when used at a concentration of 5 µM.


1.Camacho, L., Meca-Cortés, O., Abad, J.L., et al.Acid ceramidase as a therapeutic target in metastatic prostate cancerJ. Lipid Res.54(5)1207-1220(2013)

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