A cyclic pentapeptide
cyclo(RGDyC) is a cyclic pentapeptide that contains the αVβ3 integrin-binding sequence arginine-glycine-aspartate (RGD).1,2 It has been used to generate doxorubicin-containing liposomes and fluorescent silicon nanoparticles to target tumors and ocular neovasculature, respectively.
1.Amin, A., Mansourian, M., Koning, G.A., et al.Development of a novel cyclic RGD peptide for multiple targeting approaches of liposomes to tumor regionJ. Control Release220(Pt A)308-315(2015) 2.Tang, M., Ji, X., Xu, H., et al.Photostable and biocompatible fluorescent silicon nanoparticles-based theranostic probes for simultaneous imaging and treatment of ocular neovascularizationAnal. Chem.90(13)8188-8195(2018)
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