SIKVAV (acetate)

A laminin α1-derived peptide

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库存: 现货

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促销价

数量
100mg

￥737.00

590.00

- +
500mg

￥3275.00

2620.00

- +
1g

￥5750.00

4600.00

- +

已选 0 种 0 瓶

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货号: ajcx26356
CAS: N/A
别名: Hexapeptide-10, Ser-Ile-Lys-Val-Ala-Val
分子式: C28H53N7O8 ? XC2H4O2
分子量: 615.8
纯度: >98%
溶解度: DMF: insol,DMSO: insol,Ethanol: insol,PBS (pH 7.2): 2 mg/ml
储存: -20°C
库存: 现货

Background

SIKVAV is a laminin α1-derived peptide.¹ It binds to α3, α6, and β1 integrins and induces adhesion of CAC2 adenoid cystic carcinoma cells when used at a concentration of 1 µg/ml. SIKVAV (100 µg/ml) stimulates the proliferation and migration of primary mouse fibroblasts, as well as induces the secretion of EGF, VEGF, TGF-β, and FGF in the same cells.² Topical administration of a chitosan hydrogel containing SIKVAV promotes wound healing and angiogenesis in mice.

1.Freitas, V.M., Vilas-Boas, V.F., Pimenta, D.C., et al.SIKVAV, a laminin α1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathwayAm. J. Pathol.171(1)124-138(2007) 2.Chen, X., Zhang, M., Chen, S., et al.Peptide-modified chitosan hydrogels accelerate skin wound healing by promoting fibroblast proliferation, migration, and secretionCell Transplant.26(8)1331-1340(2017)