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  3. BIO-1211 (trifluoroacetate salt)
  • BIO-1211 (trifluoroacetate salt)
BIO-1211 (trifluoroacetate salt)的可视化放大

BIO-1211 (trifluoroacetate salt)

A peptide inhibitor of α4β1 integrin

原价
￥2687-19700
价格
￥ 2150-15760
BIO-1211 (trifluoroacetate salt)的二维码

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  • 库存: 现货
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  • 货号: ajcx26378
  • CAS: N/A
  • 别名:
  • 分子式: C36H48N6O9 ? XCF3COOH
  • 分子量: 708.8
  • 纯度: >98%
  • 溶解度: DMSO: soluble
  • 储存: -20°C
  • 库存: 现货

Background


BIO-1211 is a peptide inhibitor of α4β1 integrin (IC50 = 0.004 µM).1 It is selective for α4β1 integrin over α4β7 (IC50 = 2 µM), as well as α1β1, α5β1, α6β1, αLβ2, and αIIbβ3 (IC50s = >100 µM for all). BIO-1211 binds to α4β1 (IC50 = 1 nM) and inhibits Jurkat cell adhesion (IC50 = 4 nM). Inhaled administration of BIO-1211 (3 mg/animal) prevents carbachol-induced airway hyperresponsiveness in an ovine model of allergy-induced asthma.


1.Lin, K.c., Ateeq, H.S., Hsiung, S.H., et al.Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responsesJ. Med. Chem.42(5)920-934(1999)

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