Ac-IETD-AFC (trifluoroacetate salt)
A fluorogenic substrate for caspase-8
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包装价格促销价数量
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1mg￥737.00590.00- +
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5mg￥3275.002620.00- +
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10mg￥5412.004330.00- +
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- 货号: ajcx26380
- CAS: N/A
- 别名: N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin
- 分子式: C31H38F3N5O12 ? XCF3COOH
- 分子量: 729.7
- 纯度: ＞98%
- 溶解度: DMSO: 10 mg/ml
- 储存: -20°C
- 库存: 现货
Background
Ac-IETD-AFC is a fluorogenic substrate that can be cleaved by caspase-8 and related enzymes that recognize the amino acid sequence IETD, including caspase-3 processing enzyme, caspase-10, and granzyme B.1 Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
1.Reszka, P., Schulz, R., Methling, K., et al.Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substratesChemMedChem5(1)103-117(2010)
