Ac-IETD-AFC (trifluoroacetate salt)

A fluorogenic substrate for caspase-8

原价

￥737-5412

价格

￥ 590-4330

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产品引用

货号: ajcx26380
CAS: N/A
别名: N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin
分子式: C31H38F3N5O12 ? XCF3COOH
分子量: 729.7
纯度: >98%
溶解度: DMSO: 10 mg/ml
储存: -20°C
库存: 现货

Background

Ac-IETD-AFC is a fluorogenic substrate that can be cleaved by caspase-8 and related enzymes that recognize the amino acid sequence IETD, including caspase-3 processing enzyme, caspase-10, and granzyme B.¹ Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

1.Reszka, P., Schulz, R., Methling, K., et al.Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substratesChemMedChem5(1)103-117(2010)

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生命科学

有机化学

无机化学

材料科学

Ac-IETD-AFC (trifluoroacetate salt)

Ac-IETD-AFC (trifluoroacetate salt)详情

Background