- 首页
- Influenza virus
- ABT-263-d8
ABT-263-d8
An internal standard for the quantification of ABT-263
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
500ug￥1950.001560.00- +
-
1mg￥3550.002840.00- +
-
5mg￥15450.0012360.00- +
- 货号: ajcx26418
- CAS: 1217620-38-6
- 别名: 生根粉263 d8
- 分子式: C47H47ClD8F3N5O6S3
- 分子量: 982.7
- 纯度: ＞98%
- 溶解度: DMF: 30mg/mL,DMF:PBS (pH 7.2) (1:2): .3mg/mL,DMSO: 25mg/mL,Ethanol: .5mg/mL
- 储存: -20°C
- 库存: 现货
Background
ABT-263-d8 is intended for use as an internal standard for the quantification of ABT-263 by GC- or LC-MS. ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (Kis = <1, <0.5, and <1 nM, respectively).1 It is selective for Bcl-2, Bcl-xL, and Bcl-W over Mcl-1 and A1 (Kis = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC50 value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment epithelial cells (EC50 = 0.08 µM).2 ABT-263 (100 mg/kg) induces tumor regression in NCI H146 SCLC and RS4;11 acute lymphocytic leukemia (ALL) mouse xenograft models.1,3
1.Tse, C., Shoemaker, A.R., Adickes, J., et al.ABT-263: A potent and orally bioavailable Bcl-2 family inhibitorCancer Res.68(9)3421-3428(2008) 2.Bulanova, D., Ianevski, A., Bugai, A., et al.Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteinsViruses9(10)E271(2017) 3.Shoemaker, A.R., Mitten, M.J., Adickes, S., et al.Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft modelsClin. Cancer Res.14(11)3268-3277(2008)
