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- RSV (Respiratory syncytial virus)
- CP 122721 hydrochloride
CP 122721 hydrochloride
High affinity NK1 antagonist
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥2450.001960.00- +
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25mg￥9487.007590.00- +
- 货号: ajcx26810
- CAS: 145877-52-7
- 别名:
- 分子式: C20H23F3N2O2.2HCl
- 分子量: 453.33
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
High affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.
McLean et al (1996) Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J.Pharmacol.Exp.Ther. 277 900 PMID:8627572 |Gonsalves et al (1996) Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets. Eur.J.Pharmacol. 305 181 PMID:8813551 |Auais et al (2003) Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats. Am.J.Physiol. Lung Cell Mol.Physiol. 285 L105 PMID:12639840
