- 首页
- GABA Receptor
- Org 24598
Org 24598
Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
10mg￥4200.003360.00- +
-
50mg￥17375.0013900.00- +
- 货号: ajcx26844
- CAS: 372198-97-5
- 别名: N-甲基-N-[(3R)-3-苯基-3-[4-(三氟甲基)苯氧基]丙基]甘氨酸
- 分子式: C19H20F3NO3
- 分子量: 367.36
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo.
Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 |Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID:11454468 |Williams et al (2003) Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 321 31 PMID:12963052
