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NAV 26 (compound 26) 是一种选择性电压门控钠通道 Nav1.7 阻滞剂,IC50 为 0.37 μM。
Selective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866 PMID:22770500
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