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- nAChR/nAChRs (nicotinic acetylcholine receptors)
- A 85380 dihydrochloride
A 85380 dihydrochloride
High affinity and selective α4β2 nAChR agonist
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10mg￥4287.003430.00- +
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- 货号: ajcx26900
- CAS: 174740-86-4
- 别名:
- 分子式: C9H12N2O.2HCl
- 分子量: 237.13
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
High affinity and selective α4β2 nACh receptor agonist (Ki values are 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors respectively). Stimulates cation efflux in K177 cells expressing α4β2.
Abreo et al (1996) Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors. J.Med.Chem. 39 817 PMID:8632405 |Sullivan et al (1996) A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity α4β2 nicotinic acetylcholine receptor ligand. Neuropharmacology 35 725 PMID:8887981
