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- GABA Receptor
- CLP 257
CLP 257
A KCC2 cotransporter activator
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥1100.00880.00- +
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10mg￥1737.001390.00- +
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25mg￥3600.002880.00- +
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50mg￥5937.004750.00- +
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100mg￥10250.008200.00- +
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- 货号: ajcx26974
- CAS: 1181081-71-9
- 别名:
- 分子式: C14H14FN3O2S
- 分子量: 307.34
- 纯度: ＞98%
- 溶解度: DMSO: 20 mg/ml
- 储存: Store at -20°C,unstable in solution, ready to use.
- 库存: 现货
Background
Selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.
Gagnon et al (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 19 1524 PMID:24097188
