PSNCBAM-1

A CB1 receptor antagonist

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库存: 现货

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10mg

￥4112.00

3290.00

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50mg

￥17050.00

13640.00

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货号: ajcx27004
CAS: 877202-74-9
别名: 1-(4-氯苯基)-3-[3-[6-(吡咯烷-1-基)吡啶-2-基]苯基]脲
分子式: C22H21ClN4O
分子量: 392.88
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

CB1 receptor negative allosteric modulator (IC50 values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB2 receptor. Decreases food intake and body weight in rats.

Horswill et al (2007) PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br.J.Pharmacol. 152 805 PMID:17592509 |German et al (2014) Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 57 7758 PMID:25162172