AEG 40730 dihydrochloride

IAP antagonist; induces apoptosis

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10mg

￥5725.00

4580.00

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50mg

￥23900.00

19120.00

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Background

IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.

Beug et al (2014) Smac mimetics and innate immune stimuli synergize to promote tumor death. Nat.Biotechnol. 32 182 PMID:24463573 |Galbán et al (2009) Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem.J. 417 765 PMID:18851715 |Bertrand et al (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30 689 PMID:18570872