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- Ferroptosis
- NHI 2
NHI 2
An inhibitor of LDHA
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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10mg￥4150.003320.00- +
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50mg￥16700.0013360.00- +
- 货号: ajcx27020
- CAS: 1269802-97-2
- 别名:
- 分子式: C17H12F3NO3
- 分子量: 335.28
- 纯度: ＞98%
- 溶解度: DMSO: 25 mg/ml,Ethanol: 25 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
LDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Enhances the antiproliferative effects of Gemcitabine on LPC006 and PANC-1 cells. Also inhibits ferroptosis.
Maftouh et al (2014) Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcit. against pancreatic cancer cells in hypoxia. Br.J.Cancer 110 172 PMID:24178759 |Calvaresi et al (2013) Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. Chembiochem 14 2263 PMID:24174263 |Granchi et al (2013) Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org.Biomol.Chem. 11 6588 PMID:23986182 |Jacobsen et al (2018) APD-containing cyclolipodepsipeptides target mitochondrial function in hypoxic cancer cells. Cell Chem.Biol. 25 1337 PMID:30122371
