An inducer of GRP78
BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.
Inokuchi et al (2009) Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest.Ophthalmol.Vis.Sci. 50 334 PMID:18757512 |Oida et al (2008) Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 1208 217 PMID:18395193 |Kudo et al (2008) A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 15 364 PMID:18049481
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