CGP 74514 dihydrochloride
Potent cdk1 inhibitor
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包装价格促销价数量
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10mg￥3175.002540.00- +
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50mg￥13100.0010480.00- +
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- 货号: ajcx27068
- CAS: N/A
- 别名:
- 分子式: C19H24ClN7.2HCl
- 分子量: 458.82
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.
Yu et al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822 PMID:12702569 |Furet et al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 403 PMID:10896313
