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- WAY 181187 oxalate
WAY 181187 oxalate
WAY-181187 (SAX-187) oxalate 是一种有效的选择性全 5-HT6 受体激动剂，Ki 为 2.2 nM，EC50 为 6.6 nM。
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包装价格促销价数量
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10mg￥4200.003360.00- +
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50mg￥17287.0013830.00- +
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- 货号: ajcx27136
- CAS: 1883548-85-3
- 别名: SAX-187 oxalate
- 分子式: C15H13ClN4O2S2.C2H2O4
- 分子量: 470.91
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
High affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.
Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241 PMID:25837696 |Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535 PMID:17948978
