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安捷凯生物医药，安捷凯化学
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  2. Reactive oxygen species (ROS)
  3. LCB 03-0110 dihydrochloride
  • LCB 03-0110 dihydrochloride
LCB 03-0110 dihydrochloride的可视化放大

LCB 03-0110 dihydrochloride

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

原价
￥4412-18300
价格
￥ 3530-14640
LCB 03-0110 dihydrochloride的二维码

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  • 库存: 现货
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  • 货号: ajcx27138
  • CAS: N/A
  • 别名:
  • 分子式: C24H23N3O2S.2HCl
  • 分子量: 490.45
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.



Sun et al (2012) LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J.Pharmacol.Exp.Ther. 340 510 PMID:22128347

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