ITH 12575 是 CGP37157 的衍生物，是一种有效的选择性 mNCX 阻滞剂。
Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor. Reduces Ca2+ efflux from the mitochondria to the cytosol in HeLa cells (EC50 = 0.69 μM). Protects against glutamate-induced excitotoxitiy in rat hippocampal slices and oligomycin A/rotenone induced oxidative stress in neuroblastoma cells in vitro.
Martínez-Sanz et al (2015) Benzothiazepine CGP37157 analogues exert cytoprotection in various in vitro models of neurodegeneration. ACS Chem.Neurosci. 6 1626 PMID:26192029 |Moreno-Ortega et al (2015) Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology 95 503 PMID:25908402
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