PF 06260933 dihydrochloride
MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK
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包装价格促销价数量
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10mg￥3625.002900.00- +
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50mg￥14900.0011920.00- +
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- 货号: ajcx27214
- CAS: N/A
- 别名:
- 分子式: C16H13ClN4.2HCl
- 分子量: 369.68
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.
Ammirati et al (2015) Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment. ACS Med.Chem.Lett. 6 1128 PMID:26617966
