P-3FAX-Neu5Ac

Sialic acid analog; sialyltransferase inhibitor

原价

￥4675-4675

价格

￥ 3740-3740

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库存: 现货

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产品引用

货号: ajcx27220
CAS: 117405-58-0
别名:
分子式: C22H30FNO14
分子量: 551.47
纯度: >98%
溶解度: 55.15mg/ml in DMSO; 27.57mg/ml in ethanol
储存: Store at -20°C
库存: 现货

Background

Cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.

Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661 PMID:22683610 |Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733 PMID:25575241

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信号通路

生命科学

有机化学

无机化学

材料科学

P-3FAX-Neu5Ac

P-3FAX-Neu5Ac详情

Background