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- Ribosomal S6 Kinase (RSK)
- CATPB
CATPB
CATPB 是一种有效的选择性游离脂肪酸受体 2 (FFA2R/GPR43) 拮抗剂。
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包装价格促销价数量
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10mg￥3375.002700.00- +
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50mg￥13937.0011150.00- +
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- 货号: ajcx27292
- CAS: 1322598-09-3
- 别名:
- 分子式: C19H17ClF3NO3
- 分子量: 399.79
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
FFA2 inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.
Park et al (2016) Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 771 1 PMID:26683635 |Sergeev et al (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 291 303 PMID:26518871
