M 30 dihydrochloride
M 30 dihydrochloride 是一种具有口服活性、脑渗透性和脑选择性的不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。
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包装价格促销价数量
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5mg￥1912.001530.00- +
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25mg￥7400.005920.00- +
- 货号: ajcx27358
- CAS: 64821-19-8
- 别名:
- 分子式: C14H14N2O.2HCl
- 分子量: 299.2
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.
Zheng et al (2005) Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons. Biochem.Pharmacol. 70 1642 PMID:16226724 |Zheng (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J.Neurochem. 95 68 PMID:16181413 |Gal et al (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal DA depletion. J.Neurochem. 95 79 PMID:16181414
