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  2. RIP kinase
  3. P21d hydrochloride
  • P21d hydrochloride
P21d hydrochloride的可视化放大

P21d hydrochloride

Potent and selective Brk inhibitor

原价
￥3287-3287
价格
￥ 2630-2630
P21d hydrochloride的二维码

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  • 库存: 现货
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  • 货号: ajcx27362
  • CAS: N/A
  • 别名:
  • 分子式: C23H22FN7O2.HCl
  • 分子量: 483.93
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Potent and selective breast tumor kinase (Brk) inhibitor (IC50 = 30 nM). Exhibits >650-fold selectively for Brk over Aurora B kinase and Lck. Downregulates SNAIL protein, restores E-cadherin expression and suppresses migration in breast cancer cells. Also active in vivo and orally bioavailable.



Zeng et al (2011) Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors. Bioorg.Med.Chem.Lett 21 5870 PMID:21855335 |Ito et al (2016) PTK6 inhibition suppresses metastases of triple-negative breast cancer via SNAIL-dependent E-cadherin regulation. Cancer Res. 76 4406 PMID:27302163

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