AMP PNP (Adenylyl-imidodiphosphate tetralithium) 是一种不可水解的 ATP 类似物，可抑制 KATP 通道。
Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.
不可水解的AMP类似物。Kir6 (KATP)通道阻滞剂。抑制快速轴索运输并稳定膜质颗粒与微管的相互作用。
参考文献:
[1].Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID:2412134.
[2].Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID:4326768.
[3].Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 23 231 PMID:7805625.
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