HJC 0416 hydrochloride 是一种有效的口服活性 STAT3 抑制剂，具有比 Stattic 更强的抗癌特性。 HJC 0416 hydrochloride 是一种用于乳腺癌研究的有前途的抗癌剂。
STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC50 values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable.
Chen et al (2014) Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur.J.Med.Chem. 82 195 PMID:24904966
动态评分
0.0