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Liproxstatin-1 hydrochloride

A ferroptosis inhibitor

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Liproxstatin-1 hydrochloride的二维码
  • 库存: 现货
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  • 包装
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  • 5mg
    ¥1687.00
    1350.00
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  • 25mg
    ¥6512.00
    5210.00
    - +
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  • 货号: ajcx27386
  • CAS: 2250025-95-5
  • 别名:
  • 分子式: C19H21ClN4.HCl
  • 分子量: 377.31
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.



Friedmann Angeli et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 16 1180 PMID:25402683

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