安捷凯在线客服
- 客服:
- 电话: 13061953619
- 微信:
TC JL 37 是一种有效的、选择性的、可口服的 TYK2 抑制剂,Ki 为 1.6 nM。
Potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.
Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID:23668484
动态评分
0.0