CL 075 (3M002) 是一种具有免疫调节特性的选择性 TLR8 激动剂。
TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat.No.4287).
Gorden et al (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 174 1259 PMID:15661881 |Pang et al (2011) Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 12 55 PMID:21962237 |Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID:20511554
动态评分
0.0