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- GABA Receptor
- AC 265347
AC 265347
A calcimimetic and positive allosteric modulator of CaSR
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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10mg￥2450.001960.00- +
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50mg￥10200.008160.00- +
- 货号: ajcx27424
- CAS: 1253901-26-6
- 别名:
- 分子式: C17H17NOS
- 分子量: 283.39
- 纯度: ＞98%
- 溶解度: DMSO: 100 mM,Ethanol: 100 mM
- 储存: Store at 4°C
- 库存: 现货
Background
CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.
Cook et al (2015) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. Br.J.Pharmacol. 172 185 PMID:25220431 |Ma et al (2011) Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 337 275 PMID:21239511 |Leach et al (2016) Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell.Res. 26 574 PMID:27002221
