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- AMG 18 hydrochloride
AMG 18 hydrochloride
AMG 18 hydrochloride (AMG-18 Hydrochloride) 是单选择性 IRE1α；变构减弱IRE1α的抑制剂； RNase 活性，IC50 为 5.9 nM。
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5mg￥5137.004110.00- +
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- 货号: ajcx27426
- CAS: 2250019-92-0
- 别名: AMG-18 Hydrochloride
- 分子式: C31H29ClN6O3S.HCl
- 分子量: 637.58
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.
Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID:25589933
