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- GABA Receptor
- PZ-II-029
PZ-II-029
α6β3γ2-selective GABAA positive allosteric modulator
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥1225.00980.00- +
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25mg￥4750.003800.00- +
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- 货号: ajcx27444
- CAS: 164025-44-9
- 别名:
- 分子式: C18H15N3O3
- 分子量: 321.33
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
GABAA positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.
Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID:23472935 |Fan et al (2018) The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 140 1 PMID:30016665
