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  3. L Moses dihydrochloride
  • L Moses dihydrochloride
L Moses dihydrochloride的可视化放大

L Moses dihydrochloride

High affinity and selective PCAF bromodomain inhibitor

原价
￥3225-13362
价格
￥ 2580-10690
L Moses dihydrochloride的二维码

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  • 库存: 现货
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  • 货号: ajcx27484
  • CAS: N/A
  • 别名: L-45 dihydrochloride
  • 分子式: C21H24N6.2HCl
  • 分子量: 433.38
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

High affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM). Exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). Exhibits >4500-fold selectivity for PCAF over BRD4. Also exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).



Moustakim et al (2017) Discovery of a PCAF bromodomain chemical probe. Angew.Chem.Int.Ed. 56 827 PMID:27966810

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