KYP 2047 是一种有效的 BBB 穿透性脯氨酰寡肽酶 (POP) 抑制剂，Ki 值为 0.023 nM。 KYP 2047 通过血管生成和细胞凋亡调节减少胶质母细胞瘤的增殖。
High affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. Anti-angiogenic and neuroprotective. Brain penetrant.
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