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- Ribosomal S6 Kinase (RSK)
- MS 15203
MS 15203
MS 15203 是一种有效的选择性 GPR171 激动剂。
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包装价格促销价数量
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5mg￥1375.001100.00- +
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25mg￥5725.004580.00- +
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- 货号: ajcx27516
- CAS: 73912-52-4
- 别名: 5-甲基丙烯酰胺基间苯二甲酸,MS0015203
- 分子式: C12H11NO5
- 分子量: 249.22
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice.
Wardman et al (2016) Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake Sci.Signal. 9 PMID:27245612
