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PEN(人)是最丰富的下丘脑神经肽之一,源自前蛋白 ProSAAS,是 GPR83 的内源性配体。
Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.
Gomes et al (2016) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci.Signal 9 ra43 PMID:27117253 |Mack et al (2019) Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem Neurosci. 10 1884 PMID:30726666
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