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PEN(小鼠)(proSAAS(221-242))是许多起神经肽作用的肽的前体。
Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide. Activates phospholipase C (PLC)-mediated signaling cascade in mouse hypothalamus.
Gomes et al (2016) Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci.Signal. 9 ra43 PMID:27117253 |Mack et al (2019) Neuropeptide PEN and its receptor GPR83: distribution, signaling, and regulation. ACS Chem.Neurosci. 10 1884 PMID:30726666
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