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A 410099.1,胺是一种功能化的 IAP 配体,可用于合成 PROTAC,例如靶向 BTK 的 PROTAC(PROTAC 4 和 5)。
Functionalized IAP ligand for PROTAC? research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC? is a registered trademark of Arvinas Operations, Inc., and is used under license.
Tinworth et al (2019) PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Chem.Biol. 14 342 PMID:30807093
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